New Research – Some Thyroid Patients Do Need Liothyronine (T3) Medication to Recover from Hypothyroidism

This is a new piece of research. One of the researchers is a previous president of the American Thyroid Association. So, this paper ought to be taken on board by sceptical doctors and endocrinologists.

The research study compares T4, with T4/T3 and NDT (Natural Desiccated Thyroid extract, also referred to as DTE) treatments.

It definitely concludes that some patients do need T3 in their treatment in order to feel well and recover from hypothyroidism. This is a clear result! We need more of these types of research papers, as we know this already!

This result and this conclusion may help some readers in their discussions with their doctors and endocrinologists to get on better thyroid treatment.

If only researchers would actually sit down with those people that need a lot of T3 in order to feel well that might really open their eyes to the reality of the situation. I did suggest myself as a candidate for study many years ago to an eminent endocrinologist but I had no reply.

I still hope for more open-minded thyroid treatment within my lifetime. In the meantime, my books are a great resource that any reader can use – they are the real deal! The books are practical and will give you the tools you need in order to find your own way back to good health.

Here are the details on the paper:

“Comparative Effectiveness of Levothyroxine, Desiccated Thyroid Extract, and Levothyroxine+Liothyronine in Hypothyroidism”
Mohamed K M Shakir, Daniel I Brooks, Elizabeth A McAninch, Tatiana L Fonseca, Vinh Q Mai, Antonio C Bianco, Thanh D Hoang
The Journal of Clinical Endocrinology & Metabolism, dgab478,
Published: 29 June 2021

Here is the link to the paper:

Best wishes,


Paul Robinson

Paul Robinson is a British author and thyroid patient advocate. The focus of his books and work is on helping patients recover from hypothyroidism. Paul has accumulated a wealth of knowledge on thyroid and adrenal dysfunction and their treatment. His three books cover all of this.

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  1. Jen Andrew on 8th August 2021 at 4:42 pm

    Thank you!

    • Paul Robinson on 9th August 2021 at 9:09 am

      You’re welcome!

  2. Lucas on 28th August 2021 at 3:04 pm

    Some errors in the study:
    – The dose of t3 was given once a day instead of several times a day;
    – the dose equivalence of t4 to ndt is horrible, they would have to give much more ndt
    – dose adjustment was by TSH, instead of using free T3
    – My God, when are they going to do a study right??

    • Paul Robinson on 28th August 2021 at 5:51 pm

      Hi Lucas,
      I saw the study and its conclusions as only a ‘foot in the door’ or at least ‘a start’.

      Yes, there are flaws but when some of the well-known endocrinologists at least say that there is a benefit to using Liothyronine (T3) for some thyroid patients, then more doctors may have their minds open and follow.

      I am definitely not arguing with any of your points. We are just not in a quick game here. It will take time to change minds and anything positive from people who will be listened to is useful.

      Thanks Lucas.

      Best wishes, Paul

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