20-Year Study Dismisses Reasons for Not Prescribing T3 to Thyroid Patients – Research

Here is a 20-year observational piece of research.

It dismisses the incorrect views that T3 has adverse effects on the bones and heart! 

It confirms that T3 has no adverse effects on the heart and bones.

This disproves some of the major reasons that doctors use to avoid prescribing T3. The risk to the heart and to bone loss are the two most common reasons (excuses) used to avoid prescribing T3 to patients.

Note: The incorrect dosing of any thyroid hormone medication can cause anxiety and other side effects. There is some reference in the report to psychological side effects of T3 only, but I believe that this likely to to be due to two factors:

  1. Most doctors prescribing T3 do not know how to dose it safely and effectively. The Recovering with T3 book provides a safe and effective protocol for using T3. This protocol, when followed systematically, avoids any tissue over-stimulation. Any thyroid hormone which is used in the wrong dosage can cause tissue over-stimulation. Tissue over-stimulation can have psychological side effects. Many doctors who do prescribe T3 often attempt to use TSH, FT3 or even FT4 to manage the T3 dosing and this can result in too much or too little T3 being given. In addition, 3-4 doses of T3 per day are often not used, which is a pity as this is the safest way to spread the T3 out over the day.

  2. Patients that are eventually given T3-Only have usually been on T4 then T4/T3 or NDT first. These patients generally have more severe issues than patients who respond to T4 or T4/T3. Some of these patients may have gut issues, toxicity issues from heavy metals or other toxins, low B12 or other nutrients, sex hormone issues or a number of other problems. Part of the reason they have been given T3 may have been due to other severe issues that have been thought to be thyroid hormone-related. Some issues can result in psychological symptoms.

It is still a very useful study and it throws out the argument that has been used in the past about T3 causing heart and bone loss issues, which many of us have known was not true anyway when T3 is used properly.

Here is the article:

“Safety review of liothyronine use: a 20-year observational follow-up study”
Enrique Soto-Pedre & Graham Leese
Endocrine Abstracts (2015) 38 OC5.6 | DOI: 10.1530/endoabs.38.OC5.6

Best wishes,


Paul Robinson

Paul Robinson is a British author and thyroid patient advocate. The focus of his books and work is on helping patients recover from hypothyroidism. Paul has accumulated a wealth of knowledge on thyroid and adrenal dysfunction and their treatment. His three books cover all of this.

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